Management of Stroke


Raf Brouns
Jacques De Keyser
Ann De Smedt
Guy Nagels
Koen Putman


Robbert-Jan Van Hooff


Laetitia Yperzeele
Sylvie De Raedt
Aurelie De Vos

Technical/administrative Support

Andre Convents (Innovation advisor)
Alexis Valenzuela Espinoza (Business development)
Rita Van Dyck (Stroke nurse)
Saskia De Vos (Vascular Doppler technician)

Improving acute stroke management

A number of topics are being studied:

Prehospital care

PIs: Raf Brouns, Jacques De Keyser
PhD student: Laetitia Yperzeele
Collaborators: Robbert-Jan Van Hooff, Alexis Valenzuela Espinoza, Koen Putman, Liesbet De Wit, Guy Nagels, Ives Hubloue, Andre Convents, Rohny van de Casseye

The goal of the Prehospital Stroke Study at Universitair ziekenhuis Brussel (PreSSUB) is to develop and apply a telemedicine system for providing specialized care to stroke patients during ambulance transportation to the hospital. 

The role of biomarkers in stroke

PIs: Raf Brouns, Jacques De Keyser
PhD student: Laetitia Yperzeele
Collaborators: Dirk Hendriks (UA), Ingrid De Meester (UA), Robert Verkerk (UA), Sebastiaan Engelborghs (UA)

The diagnostic and prognostic value of biochemical parameters reflecting key processes underlying cerebral ischemia is evaluated in patients presenting with acute stroke. 

The role of dysautonomia in stroke

PIs: Raf Brouns, Jacques De Keyser
PhD students: Sylvie De Raedt, Aurelie De Vos, Laetitia Yperzeele
Collaborators: Yori Gidron

Stroke is often associated with disturbances of the autonomic nervous system. We assess the potential relation between cardiovascular autonomic dysfunction and stroke characteristics.

The effects of surface cooling in stroke

PIs: Raf Brouns, Robbert-Jan Van Hooff, Jacques De Keyser
PhD students: /
Collaborators: Ives Hubloue

Hyperthermia is an independent predictor of poor outcome in stroke patients. We assess the effects of mild therapeutic hypothermia through surface cooling in patients with acute stroke.

Factors associated with the efficacy and safety of thrombolysis and neuroprotective interventions

PIs: Raf Brouns, Jacques De Keyser
PhD students: Laetitia Yperzeele, Ann De Smedt


: Guy Nagels, Robbert-Jan Van Hooff

Using the UZ Brussel Stroke Registry, which is a prospective and blinded patient database, we investigate efficacy and safety parameters of interventions with regard to acute stroke care and secondary cerebrovascular prevention.

Improving secondary prevention

COACH (COunseling, Advice and Consolidation of Health promoting actions in stroke patients)
Optimization of long-term care is one of the cornerstones for improving outcome in stroke survivors. This requires patients’ adherence to medical treatment and lifestyle adjustments, which we attempt to improve through patient empowerment based on personalized information and coaching.
PIs: Raf Brouns, Jacques De Keyser
PhD students: Ann De Smedt
Collaborators: Koen Putman, Liesbet De Wit


Centre for Neurosciences • Vrije Universiteit Brussels • ©2017 • •
Faculty of Medicine & Pharmacie • Laarbeeklaan 103 • 1090 Brussel, BELGIUM • Tel: +32 (2) 477 64 10
Page generated in 0.0006 seconds.  •  Last update: 21 May 2015 15:23