Research facilities

 

Broad range of rat and mouse models:

  • Chemical and electrical models for epileptic seizures and chronic epilepsy
  • Models for Parkinson’s disease: 6-hydroxydopamine and lactacystin model
  • Endothelin-1 model for focal transient cerebral ischemia
  • Several genetic models e.g. astrocyte-specific beta2 adrenergic receptor knockout mouse
  • Microbore ultra-high performance liquid chromatography electrochemical detection for quantification of monoamines

 

Mouse and rat behavioural unit:

  • Locomotor activity: open field, rotational behaviour (Rotometer), neurological deficit score
  • Spatial memory: Morris water maze for rats and mice; Y maze for mice
  • Anti-depressant-like activity: forced swim test, tail suspension test

 

Stereotaxic surgery (rat and mouse) and in vivo microdialysis

 

Telemetry-based 24h video-EEG monitoring units for rodents

 

Radiotelemetric cardiac monitoring units

 

PK/PD modelling

 

Broad range of analytical equipment:

  • Liquid chromatography with electrochemical, fluorescence or ultraviolet detection for the determination of neurotransmitters and drugs
  • Nano ultra-high performance liquid chromatography coupled to tandem mass spectrometry for the determination of neuropeptides and drugs
  • Capillary electrophoresis
  • Size exclusion chromatography

 

Protein and DNA/RNA electrophoresis

 

Doppler flowmetry

 

Cell cultures (growth of neuroviruses, cell infections, quantification) and transfection

 

Immunological technique (immuno)histochemistry, Western blotting, ELISA

 

Brain histology, fluorescence microscopy

 

Nanobodies

 

DNA microarray

 

Centre for Neurosciences • Vrije Universiteit Brussels • ©2017 • www.c4n.be • info@c4n.be
Faculty of Medicine & Pharmacie • Laarbeeklaan 103 • 1090 Brussel, BELGIUM • Tel: +32 (2) 477 64 10
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